Ahead of tomorrow's oral presentation at EULAR, BMS has announced data from AVERT, its Phase 3b study of Orencia (abatacept)/MTX in early RA
Ahead of tomorrow's oral presentation at EULAR, BMS has announced
data from AVERT, its Phase 3b study of Orencia (abatacept)/MTX
in early RA [link]
- 351 patients with RA for 2yrs, anti-ccp positive and DAS28 CRP>3.2 were randomized to receive MTX, Orencia
(abatacept; 125mg qw) or a combination of the two treatments
- Patients were naive to biologics and MTX
- DAS28 CRP remission at 12mo was improved from 45% with MTX alone to 61% with an MTX/Orencia combo
- MRI reported progression (synovitis, osteitis and joint
erosion) was also improved with the combination therapy
- Maintenance of remission over 6mo following the withdrawal of
all RA drug therapies (co-primary endpoint) was also higher in
patients previously receiving Orencia/MTX (15% vs 8% with MTX
alone)
Comments: Further details will be reported on tomorrow
however a number of questions spring to mind. In particular, what
is the mean time to loss of response and are there any
biomarkers/baseline characteristics that predict loss of response?
In particular if remission is maintained for a period that is
considerably longer than 1wk, maintenance with less frequent Orencia
(including the possibility of biomarker tailored injection
frequency) may offer potential for future study
This content is part of UpdatesPlus' coverage of EULAR. UpdatesPlus provides expert analysis of scientific, clinical, regulatory and commercial information across a range of inflammation therapy areas. In addition to ad hoc alerts we package all analysis into a monthly PDF. For details or to register please contact fiona.watts@leaddiscovery.co.uk
This content is part of UpdatesPlus' coverage of EULAR. UpdatesPlus provides expert analysis of scientific, clinical, regulatory and commercial information across a range of inflammation therapy areas. In addition to ad hoc alerts we package all analysis into a monthly PDF. For details or to register please contact fiona.watts@leaddiscovery.co.uk
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